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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of standard equipment.
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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid, and it also helps to reduce bias in the results. However, too much heterogeneity can cause issues with the design of the trial.
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The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They also provide a useful method of determining the causality between an intervention and its outcomes. However, they shouldn't be used to substitute for explanation trials.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as follow-up.
find out this here of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary-care settings.